Centanafadine hydrochloride產品詳細介紹

型號：

訪問量：3649發(fā)布時間：2021/8/18 單位：MedChemExpress

1
產品概述

Centanafadine hydrochloride產品介紹：
Centanafadine (hydrochloride) 是去甲腎上腺素(NE)/多巴胺(DA)轉運的雙抑制劑，還能抑制5-羥色胺(serotonin)轉運體，其對人 NE，DA 和5-羥色胺轉運體的IC50值分別為6 nM，38 nM 和 83 nM。

2
產品參數(shù)

Centanafadine hydrochloride產品參數(shù)：
CAS No.：923981-14-0
MCE 際站：Centanafadine hydrochloride
產品活性：Centanafadine (hydrochloride) 是去甲腎上腺素(NE)/多巴胺(DA)轉運的雙抑制劑，還能抑制5-羥色胺(serotonin)轉運體，其對人 NE，DA 和5-羥色胺轉運體的IC50值分別為6 nM，38 nM 和 83 nM。
研究領域：GPCR/G Protein|Neuronal Signaling
作用靶點：Adrenergic Receptor|Dopamine Transporter|Serotonin Transporter
In Vitro：Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters with IC50 values of 6 and 38 nM, respectively, for NE and DA transporters, Centanafadine has lesser effects on 5-HT transporter as it inhibits the reuptake of 5-HT with an IC50 value of 83 nM .
In Vivo：In microdialysis studies, Centanafadine markedly increases NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increases DA extracellular concentrations in the striatum to 400% of baseline concentrations. Behavioral studies demonstrate that Centanafadine dose-dependently decreases immobility in the mouse tail suspension test of depression to 13% of control levels, and do not stimulate locomotor activity in adult rats in the optimal dose range.
Centanafadine dose-dependently inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternally) as neonates; a well-established animal model for attention-deficit hyperactivity disorder (ADHD).

3
相關產品

4
品牌介紹

品牌介紹：
MCE (MedChemExpress) 擁有數(shù)百種全球獨家化合物，我們致力于為全球科研客戶提供zui新zui全的品質小分子活性化合物；
10,000 多種選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領域；
設有業(yè)的實驗中心和嚴格的質控、驗證體系；
提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的純度、品質；
產品的生物活性多經(jīng)各客戶實驗驗證；
Nature, Cell, Science 等多種頂級期刊及制藥利收錄了MCE客戶的科研成果；
業(yè)團隊跟蹤zui新的制藥及生命科學研究進展，為您提供全球zui新的活性化合物；
與世界各大制藥公司及知名科研機構建立了長期的合作。